Protection induced in broiler chickens following drinking-water delivery of live infectious laryngotracheitis vaccines against subsequent challenge with recombinant field virus

MG Korsa; GF Browning; MJC Coppo; AR Legione; JR Gilkerson; AH Noormohammadi; PK Vaz; SW Lee; JM Devlin; CA Hartley

Journal article

Protection induced in broiler chickens following drinking-water delivery of live infectious laryngotracheitis vaccines against subsequent challenge with recombinant field virus

MG Korsa, GF Browning, MJC Coppo, AR Legione, JR Gilkerson, AH Noormohammadi, PK Vaz, SW Lee, JM Devlin, CA Hartley

Plos One | PUBLIC LIBRARY SCIENCE | Published : 2015

DOI: 10.1371/journal.pone.0137719

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Abstract

Infectious laryngotracheitis virus (ILTV) causes acute upper respiratory tract disease in chickens. Attenuated live ILTV vaccines are often used to help control disease, but these vaccines have well documented limitations, including retention of residual virulence, incomplete protection, transmission of vaccine virus to unvaccinated birds and reversion to high levels of virulence following bird-to-bird passage. Recently, two novel ILTV field strains (class 8 and 9 ILTV viruses) emerged in Australia due to natural recombination between two genotypically distinct commercial ILTV vaccines. These recombinant field strains became dominant field strains in important poultry producing areas. In Vic..

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University of Melbourne Researchers

Glenn Browning Author

Mauricio Coppo Author

Alistair Legione Author

James Gilkerson Author

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Funding Acknowledgements

This work was supported by the Rural Industries Research and Development Corporation (RIRDC, PRJ-008792) and by the Australian Research Council (ARC, DP130103991). JMD is supported by an ARC Future Fellowship (FT140101287). The ARC had no role in study design, data collection and analysis, decision to publish or preparation of the manuscript. The RIRDC contributed to the study design and approved the manuscript for publication, but had no role in data collection and analysis or preparation of the manuscript.